The city was founded originally in the vicinity of an Egyptian settlement named Rhacotis (that became the Egyptian quarter of the city). Alexandria grew rapidly, becoming a major centre of Hellenic civilisation and replacing Memphis as Egypt’s capital during the reign of the Ptolemaic pharaohs who succeeded Alexander. It retained this status for almost a millennium, through the period of Roman and Eastern Roman rule until the Muslim conquest of Egypt in 641 AD, when a new capital was founded at Fustat (later absorbed into Cairo).

Alexandria was best known for the Lighthouse of Alexandria (Pharos), one of the Seven Wonders of the Ancient World; its Great Library, the largest in the ancient world; and the Catacombs of Kom El Shoqafa, one of the Seven Wonders of the Middle Ages. Alexandria was the intellectual and cultural center of the ancient Mediterranean for much of the Hellenistic age and late antiquity.

It was at one time the largest city in the ancient world before being eventually overtaken by Rome.